N-Iodosuccinimide → HCID 178516695, compound
Reaction equation
[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][C:8]=2[OH:10])[CH:3]=[CH:2]1.[I:11]N1C(=O)CCC1=O>C(#N)C>[I:11][C:7]1[C:8]([OH:10])=[C:9]2[S:1][CH:2]=[CH:3][C:4]2=[N:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of thieno[3,2-b]pyridin-7-ol (from Aldrich) (0.54 g, 3.6 mmol) and N-iodosuccinimide (0.88 g, 3.9 mmol) in acetonitrile (10 mL) was heated at reflux overnight. The mixture was concentrated under reduced pressure to give the desired product which was used in the next step without further purification. LCMS calculated for C7H5INOS (M+H)+: m/z=277.9. Found: 277.8.
Workup
- temperaturewas heated
- temperatureat reflux overnight
- concentrationThe mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-ea054b2c91ae4a20a0453632b40f7930
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09181271B2
Reaction notes
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