tert-Butyl carbamate → HCID 71204722, compound
Reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([NH:22][C:23]([C@H:25]3[CH2:29][C:28]([CH3:31])([CH3:30])[CH2:27][N:26]3C(OC(C)(C)C)=O)=[O:24])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1)=[O:12]>>[CH3:30][C:28]1([CH3:31])[CH2:27][NH:26][C@@H:25]([C:23]([NH:22][C:19]2([C:16]3[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=3)[CH2:21][CH2:20]2)=[O:24])[CH2:29]1Participants
3
Procedure
The title compound (D108) (70 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from (R)-tert-butyl 2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-4,4-dimethylpyrrolidine-1-carboxylate (D75) (94 mg).
Sources & evidence
- ORD record
- ord-5fb6ca99036c472c87c7bae071f64b02
- Source dataset
- uspto-grants-2015_11
- Patent number