2-Aminobiphenyl → N2,N4-bis(2-phenylphenyl)-5-methyl-2,4-pyrimidinediamine

HRID 71372

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.Cl[C:15]1[N:20]=[C:19](Cl)[C:18]([CH3:22])=[CH:17][N:16]=1>>[C:8]1([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:15]2[N:20]=[C:19]([NH:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:18]([CH3:22])=[CH:17][N:16]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

Reactant 2

HCID 70152-Aminobiphenyl

HCID 74508Pyrimidine, 2,4-dichloro-5-methyl-

Product 1

HCID 22060710N2,N4-bis(2-phenylphenyl)-5-methyl-2,4-pyrimidinediamine

Procedure

In like manner to the preparation of 5-fluoro-N2,N4-bis(3-hydroxyphenyl)-2,4-pyrimidinediamine, 2-aminobiphenyl and 2,4-dichloro-5-methylpyrimidine were reacted to provide N2,N4-bis(2-phenylphenyl)-5-methyl-2,4-pyrimidinediamine. LCMS: ret. time: 30.47 min.; purity: 91%; MS (m/e): 429 (MH+).

Workup

customwere reacted

Sources & evidence

ORD record: ord-545dcb3821fb4a3cbfe6b60d9b96d913
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08822685B2

Linked notes

Loading…