HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanophenylboronic acid → (rac)-4-(8-(3,4-Dimethylphenyl)-8-hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Reactant | (rac)-4-Bromo-8-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol | HCID 89846267 | — |
| Product | (rac)-4-(8-(3,4-Dimethylphenyl)-8-hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile | HCID 71811407 | 79% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (rac)-4-bromo-8-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol (intermediate A-3) was reacted with 4-cyanophenylboronic acid to give the title compound as white powder in 79% yield. MS: 355.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-d5fc4687a2ee40b8b403260ee64fe309 |
| Source note | uspto-grants-2015_11 |