2-Chlorophenylboronic acid → HCID 69940488, compound

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([F:25])=[C:6]([CH:24]=1)[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH:14]2[CH2:16][CH2:15]2)[C:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[N:9]1.[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1B(O)O>>[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:2]1[CH:3]=[CH:4][C:5]([F:25])=[C:6]([CH2:7][N:8]2[C:12](=[O:13])[N:11]([CH:14]3[CH2:16][CH2:15]3)[C:10]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)=[N:9]2)[CH:24]=1

Participants

Reactant 2

HCID 27343222-Chlorophenylboronic acid

HCID 67407291HCID 67407291, compound

Product 1

HCID 69940488HCID 69940488, compound

Procedure

Analogously to the preparation of Example 122, 89 mg (0.15 mmol) of the compound from Example 100A were reacted with 59 mg (0.23 mmol) of 2-chlorophenylboronic acid. This gave 51 mg (73% of theory) of the target compound.

Sources & evidence

ORD record: ord-f36d21cd0a9441b9826772eafa71a1ae
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09187466B2

Reaction notes

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