HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,2,2-Tetrafluoro-3-iodopropane → 2-Chloro-4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,2,2-Tetrafluoro-3-iodopropane | HCID 542861 | — |
| Reactant | 2-Chloro-5-hydroxy-4-methylpyridine | HCID 71299549 | — |
| Product | 2-Chloro-4-methyl-5-(2,2,3,3-tetrafluoropropoxy)pyridine | HCID 89874132 | 89% |
Reaction Steps
The title compound is prepared in 89% yield (7.97 g, pale yellow solid) from 6-chloro-4-methylpyridin-3-ol (5.00 g, 34.8 mmol) and 1,1,2,2-tetrafluoro-3-iodopropane (16.9 g, 69.7 mmol) in a similar manner to Step-1 of Amine-49.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-899879fb78c84da8a2cee24eb07f6556 |
| Source note | uspto-grants-2015_11 |