Cyclobutanol → 6-Cyclobutoxy-5-methylnicotinic acid
Reaction equation
F[C:2]1[C:10]([CH3:11])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH:12]1([OH:16])[CH2:15][CH2:14][CH2:13]1>>[CH:12]1([O:16][C:2]2[C:10]([CH3:11])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=2)[CH2:15][CH2:14][CH2:13]1Participants
3
Procedure
The title compound is prepared in 88% yield (1.18 g, white solid) from 6-fluoro-5-methylnicotinic acid (1.00 g, 6.45 mmol) and cyclobutanol (837 mg, 11.6 mmol) in a similar manner to Step-1 of Amine-1.
Sources & evidence
- ORD record
- ord-a800879334514e89957156ffc0540ca4
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09187475B2
Reaction notes
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