4-(Aminomethyl)benzonitrile → N-(imidazo[1,2-a]pyridin-6-ylmethyl)-2-((tetrahydrofuran-2-yl)methylamino)thiazole-5-carboxamide
Reaction equation
[C:1]([C:3]1C=C[C:6](CN)=[CH:5][CH:4]=1)#[N:2].Br[C:12]1[S:13][C:14]([C:17]([NH:19][CH2:20][C:21]2[CH:22]=[CH:23][C:24]3[N:25]([CH:27]=[CH:28][N:29]=3)[CH:26]=2)=[O:18])=[CH:15][N:16]=1.BrC1SC(C(NC2C=CC3N(C=CN=3)C=2)=[O:37])=CN=1>>[N:29]1[CH:28]=[CH:27][N:25]2[CH:26]=[C:21]([CH2:20][NH:19][C:17]([C:14]3[S:13][C:12]([NH:2][CH2:1][CH:3]4[CH2:4][CH2:5][CH2:6][O:37]4)=[N:16][CH:15]=3)=[O:18])[CH:22]=[CH:23][C:24]=12Participants
4
Reactant 3
Product 1
Procedure
The title compound was prepared as in Example 53B, substituting (tetrahydrofuran-2-yl)methanamine for 4-cyanobenzylamine and 2-bromo-N-(imidazo[1,2-a]pyridin-6-ylmethyl)thiazole-5-carboxamide for 2-bromo-N-(imidazo[1,2-a]pyridin-6-yl)thiazole-5-carboxamide.