tert-butyl (S)-2-[6-bromo-3-bis-(tert-butoxycarbonyl)amino-2-methoxycarbonylphenoxy-methyl]pyrrolidine-1-carboxylate → methyl 6-amino-3-bromo-2-((S)-1-pyrrolidin-2-ylmethoxy)benzoate
Reaction equation
[NH2:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([O:12][CH2:13][C@H:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)[C:5]([Br:19])=[CH:4][CH:3]=1.BrC1C(OC[C@@H]2CCCN2C(OC(C)(C)C)=O)=C(C(OC)=O)C(N(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)=CC=1>>[NH2:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([O:12][CH2:13][C@@H:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)[C:5]([Br:19])=[CH:4][CH:3]=1Participants
3
Reactant 2
Product 1
Procedure
Prepared by proceeding in a similar manner to Intermediate 7, starting from tert-butyl (S)-2-[6-bromo-3-bis-(tert-butoxycarbonyl)amino-2-methoxycarbonylphenoxy-methyl]pyrrolidine-1-carboxylate (Intermediate 15).