Octanoic hydrazide → 7-Chloro-4-hydroxy-1-methyl-N'-octanoyl-2-oxo-1,2-dihydroquinoline-3-carbohydrazide

HRID 716700

Reaction equation

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:19])=[C:7]([C:14]([O:16]CC)=O)[C:8](=[O:13])[N:9]2[CH3:12])=[CH:4][CH:3]=1.[C:20]([NH:29][NH2:30])(=[O:28])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:19])=[C:7]([C:14]([NH:30][NH:29][C:20](=[O:28])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:16])[C:8](=[O:13])[N:9]2[CH3:12])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 80556Octanoic hydrazide

HCID 54732594Ethyl 7-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

Product 1

HCID 715476557-Chloro-4-hydroxy-1-methyl-N'-octanoyl-2-oxo-1,2-dihydroquinoline-3-carbohydrazide

Procedure

Reagents: Comp 39 (0.36 mmols, 0.1 g); octanoyl hydrazine (0.39 mmols, 0.063 g). Yield: 0.07 g (50%), white solid, m.p.=164° C.-165° C.

Sources & evidence

ORD record: ord-9f337eb9e0324a618061fc1f58f681bc
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09193688B2

Linked notes

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