(2-Amino-4-iodo-phenyl)-carbamic acid tert-butyl ester → Tert-butyl 4-iodo-2-(3-oxo-3-(pyridazin-4-yl)propanamido)phenylcarbamate
Reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13].[O:17]=[C:18]([C:27]1[CH:32]=[CH:31][N:30]=[N:29][CH:28]=1)[CH2:19][C:20](OC(C)(C)C)=[O:21]>>[I:8][C:6]1[CH:5]=[CH:4][C:3]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[C:2]([NH:1][C:20](=[O:21])[CH2:19][C:18](=[O:17])[C:27]2[CH:32]=[CH:31][N:30]=[N:29][CH:28]=2)[CH:7]=1Participants
3
Procedure
The title compound was prepared from the reaction of tert-butyl 2-amino-4-iodophenylcarbamate (Example B3; 1 mmol) and tert-butyl 3-oxo-3-(pyridazin-4-yl)propanoate (Example C1; 1 mmol) according to the general procedure D. Obtained as a yellow solid (87%), MS (EI) 483 [(M+1)+].
Sources & evidence
- ORD record
- ord-1cba53e510224bad998810e1dd8f42ee
- Source dataset
- uspto-grants-2015_11