2-(3-Methoxycarbonylamino-2-oxo-piperidin-1-yl)-propionic acid ethyl ester → 2-(3-Methoxycarbonylamino-2-oxo-piperidin-1-yl)-propionic acid

HRID 71755

Reaction equation

HRID 71755 reaction equation
C([O:3][C:4](=[O:19])[CH:5]([N:7]1[CH2:12][CH2:11][CH2:10][CH:9]([NH:13][C:14]([O:16][CH3:17])=[O:15])[C:8]1=[O:18])[CH3:6])C.COC(N1CC(=O)N2C(C(OCC)=O)CCC2C1)=O>>[CH3:17][O:16][C:14]([NH:13][CH:9]1[CH2:10][CH2:11][CH2:12][N:7]([CH:5]([CH3:6])[C:4]([OH:19])=[O:3])[C:8]1=[O:18])=[O:15]

Participants

3

Reactant 2

HCID 666201642-(3-Methoxycarbonylamino-2-oxo-piperidin-1-yl)-propionic acid ethyl esterHCID 666205494-Oxo-hexahydro-pyrrolo[1,2-a]pyrazine-2,6-dicarboxylic acid 6-ethyl ester 2-methyl ester

Product 1

HCID 666210692-(3-Methoxycarbonylamino-2-oxo-piperidin-1-yl)-propionic acid

Procedure

2-(3-Methoxycarbonylamino-2-oxo-piperidin-1-yl)-propionic acid was prepared by method 801 substituting 2-(3-methoxycarbonylamino-2-oxo-piperidin-1-yl)-propionic acid ethyl ester for 4-oxo-hexahydro-pyrrolo[1,2-a]pyrazine-2,6-dicarboxylic acid 6-ethyl ester 2-methyl ester. C10H16N2O5 calculated 244.1 observed [M+1]+ 245.1; rt=1.53 min.

Workup

  1. customrt=1.53 min.

Sources & evidence

ORD record
ord-969bde2042524a588fca7d1e8f6d3de3
Source dataset
uspto-grants-2014_09
Patent number
US08822430B2

Linked notes

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