4-((6-Methoxybenzofuran-2-yl)ethynyl)phenyl acetate → 4-(2-(6-Methoxy-2,3-dihydrobenzofuran-2-yl)ethyl)phenol

Participants

Reaction Steps

When the product of Step A was substituted for N-(6,6-dimethyl bicyclo[3.1.1]heptan-2-yl)-4-(4-hydroxybut-1-ynyl)benzenesulphonamide in Example 18, Step C, the similar process (higher pressure of H2) afforded the title compound in 96% yield, as creamy paste. 1H-NMR (CDCl3) 7.25-7.19 (m, 2H); 7.02-6.97 (m, 3H); 6.38-6.35 (m, 2H); 4.81-4.72 (m, 1H); 3.75 (s, 3H); 3.24-3.16 (m, 1H); 2.83-2.73 (m, 3H); 2.27 (s, 3H); 2.13-2.07 (m, 1H); 2.06-1.92 (m, 1H).

Provenance & Evidence