2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 131734178, compound

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[NH:11][N:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:14][Si:15]([CH2:18][CH2:19][O:20][CH2:21]Cl)([CH3:17])[CH3:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[N:11]([CH2:21][O:20][CH2:19][CH2:18][Si:15]([CH3:17])([CH3:16])[CH3:14])[N:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl ether

HCID 1362439061-(4-Bromophenyl)-1,2-dihydro-5H-tetrazol-5-one

Product 1

HCID 131734178HCID 131734178, compound

Procedure

Compound 53a was treated with SEMCl as described in Example 51, Step C to obtain compound 53b as a white solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C13H19BrN4O2Si: 371.0 (M+H). Found 371.1.

Sources & evidence

ORD record: ord-1b06f4f8f07e400eb0f0f403ace73653
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09193736B2

Reaction notes

Loading…