Bromine → HCID 178524228, compound
Reaction equation
[OH:1][C:2]1[C:7]2=[CH:8][CH:9]=[C:10]3[C:19]([N:18]=[C:17]4[C:12]([CH:13]=[CH:14][CH:15]=[C:16]4[C:20]([OH:22])=[O:21])=[N:11]3)=[C:6]2[CH:5]=[CH:4][CH:3]=1.[Br:23]Br>C(Cl)(Cl)Cl>[Br:23][C:3]1[CH:4]=[CH:5][C:6]2=[C:19]3[C:10](=[CH:9][CH:8]=[C:7]2[C:2]=1[OH:1])[N:11]=[C:12]1[C:17]([C:16]([C:20]([OH:22])=[O:21])=[CH:15][CH:14]=[CH:13]1)=[N:18]3Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 4-hydroxy-benzo[a]phenazine-11-carboxylic acid (see Reference Example 1K, 102 mg) and bromine (0.04 mL) was stirred in chloroform (3 mL) at room temperature for 20 hours. The solvent was removed in vacuo and the residue was purified using flash chromatography (10% methanol in dichloromethane) to yield the title compound (24 mg) as a yellow-brown solid.