2-Amino-4-(3-nitrophenyl)thiazole → HCID 10135798, compound

HRID 719306

Reaction equation

HRID 719306 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:6]=1.[CH2:16]([C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1)[CH2:17][CH3:18]>>[N+:13]([C:9]1[CH:8]=[C:7]([C:5]2[N:6]=[C:2]([NH:1][S:25]([C:22]3[CH:23]=[CH:24][C:19]([CH2:16][CH2:17][CH3:18])=[CH:20][CH:21]=3)(=[O:27])=[O:26])[S:3][CH:4]=2)[CH:12]=[CH:11][CH:10]=1)([O-:15])=[O:14]

Participants

3

Reactant 2

HCID 6135042-Amino-4-(3-nitrophenyl)thiazoleHCID 27372224-N-Propylbenzenesulphonyl chloride

Product 1

HCID 10135798HCID 10135798, compound

Procedure

The title compound was prepared from 2-amino-4-(3-nitrophenyl)thiazole and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (41.5 mg) with purity >90%: MS (pos) m/z 404.1, (neg) m/z 402.2; HRMS m/z 403.0062 (calc. of monoisotopic mass for Cl18H17N3O4S2 gives 403.0060).

Sources & evidence

ORD record
ord-b4b89f8535a04d2ab8c91439b7586ed6
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Linked notes

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