2-Amino-4-(4-methoxyphenyl)thiazole → 2,4,6-trichloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 719314

Reaction equation

HRID 719314 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([NH2:14])[S:12][CH:13]=2)=[CH:5][CH:4]=1.[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([Cl:23])[C:17]=1[S:24](Cl)(=[O:26])=[O:25]>>[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([Cl:23])[C:17]=1[S:24]([NH:14][C:11]1[S:12][CH:13]=[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[N:10]=1)(=[O:26])=[O:25]

Participants

3

Reactant 2

HCID 1596442-Amino-4-(4-methoxyphenyl)thiazoleHCID 5213352,4,6-Trichlorobenzenesulfonyl chloride

Product 1

HCID 101147862,4,6-trichloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]benzenesulfonamide

Procedure

The title compound was prepared from 4-(4-methoxy-phenyl)-thiazol-2-ylamine and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic MEIHOD B to give a white-yellow solid (58.2 mg) with purity >90%. MS (pos) m/z 449.1, 451.1, 453.1.

Sources & evidence

ORD record
ord-0af05847f737479084086a2f83fd0da0
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Linked notes

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