4-(2-Chlorophenyl)-1,3-thiazol-2-amine → N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-4-propylbenzenesulfonamide

HRID 719322Notes

Reaction equation

HRID 719322 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[C:10]([NH2:13])[S:11][CH:12]=1.[CH2:14]([C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1)[CH2:15][CH3:16]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[C:10]([NH:13][S:23]([C:20]2[CH:21]=[CH:22][C:17]([CH2:14][CH2:15][CH3:16])=[CH:18][CH:19]=2)(=[O:25])=[O:24])[S:11][CH:12]=1

Participants

3

Reactant 2

HCID 2247644-(2-Chlorophenyl)-1,3-thiazol-2-amineHCID 27372224-N-Propylbenzenesulphonyl chloride

Product 1

HCID 10111147N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-4-propylbenzenesulfonamide

Procedure

The title compound was prepared from 4-(2-chlorophenyl)-1,3-thiazol-2-amine and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (30.9 mg) with purity >90%. MS (pos) m/z 393.1.

Sources & evidence

ORD record
ord-d5f62ac878cf4a1bb069aab3742857fa
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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