4-(2-Chlorophenyl)-1,3-thiazol-2-amine → 3-Chloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide

HRID 719328

Reaction equation

HRID 719328 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[C:10]([NH2:13])[S:11][CH:12]=1.[Cl:14][C:15]1[C:16]([CH3:25])=[C:17]([S:21](Cl)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1>>[Cl:14][C:15]1[C:16]([CH3:25])=[C:17]([S:21]([NH:13][C:10]2[S:11][CH:12]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[N:9]=2)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 2247644-(2-Chlorophenyl)-1,3-thiazol-2-amineHCID 5227343-Chloro-2-methylbenzenesulfonyl chloride

Product 1

HCID 102225473-Chloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide

Procedure

The title compound was prepared from 4-(2-chlorophenyl)-1,3-thiazol-2-amine and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (45.3 mg) with purity >90%: MS (pos) m/z 399.1, 401.1; HRMS m/z 397.9711 (calc. of monoisotopic mass for C16H12Cl2N2O2S2 gives 397.9117).

Sources & evidence

ORD record
ord-0d3b769ac2cf4506be64508fa45a0116
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Linked notes

Loading…