4-(3-Pyridinyl)-2-thiazolamine → 2,4,6-Trichloro-N-[4-(3-pyridinyl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 719329

Reaction equation

HRID 719329 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:8]=[C:9]([NH2:12])[S:10][CH:11]=2)[CH:2]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:21])[C:15]=1[S:22]([NH:12][C:9]1[S:10][CH:11]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[N:8]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 1548934-(3-Pyridinyl)-2-thiazolamineHCID 5213352,4,6-Trichlorobenzenesulfonyl chloride

Product 1

HCID 101369522,4,6-Trichloro-N-[4-(3-pyridinyl)-1,3-thiazol-2-yl]benzenesulfonamide

Procedure

The title compound was prepared from 4-(3-pyridyl)-1,3-thiazol-2-amine and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (29.3 mg) with purity >90%: MS (pos) m/z 422.1; HRMS m/z 418.9134 (calc. of monoisotopic mass for C14H8Cl3N3O2S2 gives 418.9123).

Sources & evidence

ORD record
ord-f6ee2e41f3e4460f9237787acfbcc012
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Linked notes

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