4-(2-Chlorophenyl)-1,3-thiazol-2-amine → 2,4,6-trichloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 719331

Reaction equation

HRID 719331 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[C:10]([NH2:13])[S:11][CH:12]=1.[Cl:14][C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([Cl:22])[C:16]=1[S:23](Cl)(=[O:25])=[O:24]>>[Cl:14][C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([Cl:22])[C:16]=1[S:23]([NH:13][C:10]1[S:11][CH:12]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[N:9]=1)(=[O:25])=[O:24]

Participants

3

Reactant 2

HCID 2247644-(2-Chlorophenyl)-1,3-thiazol-2-amineHCID 5213352,4,6-Trichlorobenzenesulfonyl chloride

Product 1

HCID 101826272,4,6-trichloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

Procedure

The title compound was prepared from 4-(2-chlorophenyl)-1,3-thiazol-2-amine and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (38.7 mg) with purity >90%. MS (pos) m/z 453.0, 455.0, 457.0.

Sources & evidence

ORD record
ord-922f0e8b11fb405b92a0640d301a2bbd
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Linked notes

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