(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 10298989, compound
Reaction equation
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=1[C:12]1[N:13]=[C:14]([NH2:17])[S:15][CH:16]=1.[C:18]1([C:24]2[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=1[C:12]1[N:13]=[C:14]([NH:17][S:30]([C:27]2[CH:26]=[CH:25][C:24]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:29][CH:28]=2)(=[O:32])=[O:31])[S:15][CH:16]=1Participants
3
Procedure
The title compound was prepared from 4-(2-chloro-5-nitrophenyl)-1,3-thiazol-2-amine hydrobromide and 4-phenylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (11.9 mg) with purity >90%. MS (pos) m/z 472.1.
Sources & evidence
- ORD record
- ord-da6e7381c17c4d1eadfa8102a0e5f2c5
- Source dataset
- uspto-grants-2006_11