3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-[4-(3-chloro-2-thienyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide

HRID 719344

Reaction equation

HRID 719344 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[N:8]=[C:9]([NH2:12])[S:10][CH:11]=1.[Cl:13][C:14]1[C:15]([CH3:24])=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[C:15]([CH3:24])=[C:16]([S:20]([NH:12][C:9]2[S:10][CH:11]=[C:7]([C:3]3[S:4][CH:5]=[CH:6][C:2]=3[Cl:1])[N:8]=2)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 14884414-(3-Chloro-2-thienyl)-1,3-thiazol-2-amine

Product 1

HCID 101359023-Chloro-N-[4-(3-chloro-2-thienyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide

Procedure

The title compound was prepared from 4-(3-chloro-2-thienyl)-1,3-thiazol-2-amine and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (7.6 mg) with purity >90%. MS (pos) m/z 405.2, 407.2.

Sources & evidence

ORD record
ord-e85357db423e44d99ecdbbda00db20af
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Linked notes

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