4-Bromo-2,5-difluorobenzenesulfonyl Chloride → HCID 11167349, compound

HRID 719352

Reaction equation

HRID 719352 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[N:8]=[C:9]([NH2:12])[S:10][CH:11]=1.[Br:13][C:14]1[C:19]([F:20])=[CH:18][C:17]([S:21](Cl)(=[O:23])=[O:22])=[C:16]([F:25])[CH:15]=1>>[Br:13][C:14]1[C:19]([F:20])=[CH:18][C:17]([S:21]([NH:12][C:9]2[S:10][CH:11]=[C:7]([C:3]3[S:4][CH:5]=[CH:6][C:2]=3[Cl:1])[N:8]=2)(=[O:22])=[O:23])=[C:16]([F:25])[CH:15]=1

Participants

3

Reactant 2

HCID 5745904-Bromo-2,5-difluorobenzenesulfonyl ChlorideHCID 14884414-(3-Chloro-2-thienyl)-1,3-thiazol-2-amine

Product 1

HCID 11167349HCID 11167349, compound

Procedure

The title compound was prepared 4-(3-chloro-2-thienyl)-1,3-thiazol-2-amine (59 mg) and 4-bromo-2,5-difluorobenzenesulfonyl chloride (79 mg) as described in the synthetic METHOD B to give a white solid (22.3 mg) with purity >90%: MS (pos) m/z 471.2, 473.2.

Sources & evidence

ORD record
ord-88a55cc7fe7b480da9407c9be3f70ed1
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Linked notes

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