2,3,4-Trichlorobenzenesulfonyl chloride → HCID 10116414, compound

HRID 719356

Reaction equation

HRID 719356 reaction equation
Br.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:15](=[CH:16][CH:17]=1)[C:10]1[N:11]=[C:12]([NH2:14])[S:13][C:9]=1[CH2:8][CH2:7]2.[Cl:18][C:19]1[C:24]([Cl:25])=[C:23]([Cl:26])[CH:22]=[CH:21][C:20]=1[S:27](Cl)(=[O:29])=[O:28]>>[Cl:18][C:19]1[C:24]([Cl:25])=[C:23]([Cl:26])[CH:22]=[CH:21][C:20]=1[S:27]([NH:14][C:12]1[S:13][C:9]2[CH2:8][CH2:7][C:6]3[C:15](=[CH:16][CH:17]=[C:4]([O:3][CH3:2])[CH:5]=3)[C:10]=2[N:11]=1)(=[O:29])=[O:28]

Participants

3

Reactant 2

HCID 369042,3,4-Trichlorobenzenesulfonyl chlorideHCID 28074737-Methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-amine hydrobromide

Product 1

HCID 10116414HCID 10116414, compound

Procedure

The title compound was prepared from 7-methoxy-4,5-dihydronaphtho(1,2-D)(1,3)thiazol-2-amine hydrobromide (85 mg) and 2,3,4-trichlorobenzenesulfonyl chloride (76 ng) as described in the synthetic METHOD B to give a white solid (13.1 mg) with purity >90%: MS (pos) m/z 475.3, 477.3

Sources & evidence

ORD record
ord-7e02e51b0dd84c419f2b2ec7f94d76d0
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Linked notes

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