(2R)-2-isobutylsuccinic acid → HCID 86593154, compound
Reaction equation
[CH2:1]([C@H:5]([CH2:9][C:10]([OH:12])=[O:11])[C:6]([OH:8])=O)[CH:2]([CH3:4])[CH3:3]>C(Cl)(=O)C>[CH2:1]([C@@H:5]1[CH2:9][C:10](=[O:11])[O:12][C:6]1=[O:8])[CH:2]([CH3:3])[CH3:4]Participants
3
Reagents, catalysts & solvents 1
Procedure
A solution of (2R)-2-isobutylsuccinic acid (35 mg, 0.2 mmol) in acetyl chloride (1.2 ml) was heated at reflux under nitrogen for 2.2 hours then volatile components removed by distillation in vacuo to leave (3R)-3-isobutyldihydrofuran-2,5-dione as an oily residue which was used without further purification.
Workup
- temperatureat reflux under nitrogen for 2.2 hours
- customvolatile components removed by distillation in vacuo
Sources & evidence
- ORD record
- ord-fe312e0a60bb4905895e7ba0ec702844
- Source dataset
- uspto-grants-2006_11
- Patent number
- US07132449B2
Reaction notes
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