Hexahydro-1,4-diazepine → N,N'-bis(5,6,7-trimethoxyindole-2-carbonyl)homopiperazine
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([OH:18])=O)=[CH:6]2.[NH:19]1[CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([N:19]1[CH2:25][CH2:24][CH2:23][N:22]([C:16]([C:7]3[NH:8][C:9]4[C:5]([CH:6]=3)=[CH:4][C:3]([O:2][CH3:1])=[C:11]([O:12][CH3:13])[C:10]=4[O:14][CH3:15])=[O:18])[CH2:21][CH2:20]1)=[O:18])=[CH:6]2Participants
3
Procedure
5,6,7-Trimethoxyindole-2-carboxylic acid (300 mg) and homopiperazine (60 mg) were reacted in the same manner as in Preparation Example 37 to obtain the title compound.
Sources & evidence
- ORD record
- ord-392f872bb6ae4481bdcdcb41aa502896
- Source dataset
- uspto-grants-2006_11
- Patent number
- US07135473B2