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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 720521Generated: October 24, 2026

Cyclohexanepropionaldehyde → (5R)-12-(2-cyclohexylethyl)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione

https://huagongshe.com/en/reaction/720521

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclohexanepropionaldehydeHCID 78070—
Reactant(5R)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dioneHCID 9929755—
Product(5R)-12-(2-cyclohexylethyl)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dioneHCID 69478257—

Reaction Steps

The product of Example 84 is treated with 3-cyclohexylpropanal according to a procedure similar to Stage 95e in order to produce the expected solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07135478B2
Source datasetuspto-grants-2006_11
ORD IDord-28a0670951cb4d05bb768d2bf53334a3
Source noteuspto-grants-2006_11