HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → L-Glutamic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | L-Glutamic acid di-tert-butyl ester | HCID 208637 | — |
| Reactant | 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate | HCID 9857522 | — |
| Reactant | Succinimidyl hexadecandioate | HCID 131727748 | — |
| Product | L-Glutamic Acid | HCID 33032 | — |
Reaction Steps
This compound was prepared in analogy with example 4, via reaction of L-Glu(OtBu)-OtBu with succinimidyl hexadecandioate followed by activation with TSTU, coupling with Des(B30) human insulin and deprotection by TFA. LCMS 6130.8, calculated 6132.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828923B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-8a8b5a6e191740d29489d0fdf6c12a18 |
| Source note | uspto-grants-2014_09 |