Methyl vinyl sulfone → 1-(2-Methanesulfonyl-ethyl)-4-(4-nitro-phenyl)-[1,4]diazepane

HRID 72208

Reaction equation

HRID 72208 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:16][CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:17][S:18]([CH:21]=[CH2:22])(=[O:20])=[O:19]>CO>[CH3:17][S:18]([CH2:21][CH2:22][N:13]1[CH2:14][CH2:15][CH2:16][N:10]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)[CH2:11][CH2:12]1)(=[O:20])=[O:19]

Participants

4

Reactant 2

HCID 19354Methyl vinyl sulfoneHCID 50559501-(4-Nitrophenyl)-1,4-diazepane

Product 1

HCID 689796131-(2-Methanesulfonyl-ethyl)-4-(4-nitro-phenyl)-[1,4]diazepane

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-(4-Nitro-phenyl)-[1,4]diazepane (4.90 g), Methansulfonyl-ethene (2.35 g) and Methanol (50 mL) was stirred for 2 h at room temperature. The volatiles were removed in vacuo. The product with the molecular weight of 327.40 (C14H21N3O4S) was obtained in this way; MS (ESI): 328 (M+H+).

Workup

  1. customThe volatiles were removed in vacuo
  2. customThe product with the molecular weight of 327.40 (C14H21N3O4S) was obtained in this way

Sources & evidence

ORD record
ord-f675f3baab6544c48293dbeb4ed82bcd
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Linked notes

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