Ethanol → 1-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazole

HRID 722197

Reaction equation

HRID 722197 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:11][NH2:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[N:13]1[CH:18]=CC=NN=1.[CH2:19](O)C>>[F:1][C:2]1[CH:3]=[C:4]([N:11]2[CH:18]=[N:13][CH:19]=[N:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 3

HCID 702EthanolHCID 1230471,2,3-TriazineHCID 21883867(3-Fluoro-4-nitrophenyl)hydrazine

Product 1

HCID 218839191-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazole

Procedure

The mixture consisting of 2.5 g of 3-fluoro-4-nitrophenylhydrazine, 1.2 g of [1,2,3]triazine and 50 ml of ethanol was heated to reflux with stirring for 6 hours. After concentrating the reaction mixture under reduced pressure, the residue was worked up by column chromatography (solvent: 99:1 dichloromethane:methanol; silica gel).

Workup

  1. temperaturewas heated
  2. temperatureto reflux
  3. concentrationAfter concentrating the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-cd957a3c7bf34e4a974ca1e5c6db13fd
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Linked notes

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