2-Chloro-4,5-difluorobenzoyl Isocyanate → HCID 178488186, compound

HRID 722202

Reaction equation

HRID 722202 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[C:21]([C:23]2[NH:27][C:26]([CH3:28])=[N:25][N:24]=2)[CH:20]=[CH:19][C:18]=1[NH2:29]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:29][C:18]1[CH:19]=[CH:20][C:21]([C:23]2[NH:27][C:26]([CH3:28])=[N:25][N:24]=2)=[CH:22][C:17]=1[O:16][CH3:15])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 115575832-Chloro-4,5-difluorobenzoyl IsocyanateHCID 178488184HCID 178488184, compound

Product 1

HCID 178488186HCID 178488186, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The solution of equivalent amounts of 2-chloro-4,5-difluorobenzoyl isocyanate was added dropwise to the solution of 30 mg of 2-methoxy-4-(5-methyl-4H-[1,2,4]triazol-3-yl)phenylamine in 3 ml of acetonitrile and the mixture was stirred at room temperature for 30 minutes. The solid was then filtered off with suction, stirred with isopropanol and dried under reduced pressure.

Workup

  1. filtrationThe solid was then filtered off with suction
  2. stirringstirred with isopropanol
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-9d63ce9c4ae741549cc6f9bc5d723dc6
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Linked notes

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