5-(2-Nitrophenyl)-1,3,4-oxadiazol-2-amine → 5-(2-Aminophenyl)-1,3,4-oxadiazol-2-amine

HRID 722219

Reaction equation

HRID 722219 reaction equation
[H][H].[N+:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[O:16][C:15]([NH2:17])=[N:14][N:13]=1)([O-])=O>>[NH2:3][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[O:16][C:15]([NH2:17])=[N:14][N:13]=1

Participants

3

Reactant 2

HCID 7120425-(2-Nitrophenyl)-1,3,4-oxadiazol-2-amineHCID 178418361HCID 178418361, compound

Product 1

HCID 50938855-(2-Aminophenyl)-1,3,4-oxadiazol-2-amine

Procedure

Hydrogen was introduced at atmospheric pressure into the solution of 350 mg of 5-(2-nitrophenyl)-[1,3,4]oxadiazol-2-ylamine until the theoretical amount had been taken up. After filtering off the catalyst with suction and concentrating the mixture under reduced pressure, the remaining oily residue was purified by column chromatography (solvent: 95:5 dichloromethane/methanol; silica gel).

Workup

  1. filtrationAfter filtering off the catalyst with suction
  2. concentrationconcentrating the mixture under reduced pressure
  3. customthe remaining oily residue was purified by column chromatography (solvent: 95:5 dichloromethane/methanol; silica gel)

Sources & evidence

ORD record
ord-d726a4112522467aa7270fe17a87f474
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Linked notes

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