(Cyclopropylmethyl)methylamine → 1-(4-Cyclopentyloxyphenyl)-3-{4-[2-(cyclopropylmethyl(methyl)amino)-ethoxy]phenyl}-1,3-dihydroimidazol-2-one

HRID 723371

Reaction equation

HRID 723371 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[CH:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)=[CH:18][CH:17]=3)[C:12]2=[O:28])=[CH:7][CH:6]=1.[CH:29]1([CH2:32][NH:33][CH3:34])[CH2:31][CH2:30]1>>[CH:23]1([O:22][C:19]2[CH:18]=[CH:17][C:16]([N:13]3[CH:14]=[CH:15][N:11]([C:8]4[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][N:33]([CH2:32][CH:29]5[CH2:31][CH2:30]5)[CH3:34])=[CH:6][CH:7]=4)[C:12]3=[O:28])=[CH:21][CH:20]=2)[CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 12919209(Cyclopropylmethyl)methylamineHCID 218733301-[4-(2-Bromoethoxy)phenyl]-3-(4-cyclopentyloxyphenyl)-1,3-dihydroimidazol-2-one

Product 1

HCID 218733151-(4-Cyclopentyloxyphenyl)-3-{4-[2-(cyclopropylmethyl(methyl)amino)-ethoxy]phenyl}-1,3-dihydroimidazol-2-one

Procedure

1-[4-(2-Bromoethoxy)phenyl]-3-(4-cyclopentyloxyphenyl)-1,3-dihydroimidazol-2-one was reacted with cyclopropylmethyl(methyl)amine as described in example 5. The product with the molecular weight of 447.58 (C27H33N3O3); MS (ESI): 448 ([M+H]+) was obtained in this way.

Workup

  1. customMS (ESI): 448 ([M+H]+) was obtained in this way

Sources & evidence

ORD record
ord-22509260bd84463ea32860c5405bc0a4
Source dataset
uspto-grants-2006_11
Patent number
US07141561B2

Linked notes

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