2-(2,5-Dioxoimidazolidin-1-yl)acetic acid → 2-(2,5-Dioxo-imidazolidin-1-yl)-N-{4-[2-oxo-3-(4-phenoxy-phenyl)-2,3-dihydroimidazol-1-yl]-phenyl}-acetamide

HRID 723376

Reaction equation

HRID 723376 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:15][CH:14]=3)[C:9]2=[O:26])=[CH:4][CH:3]=1.[O:27]=[C:28]1[NH:32][CH2:31][C:30](=[O:33])[N:29]1[CH2:34][C:35](O)=[O:36]>>[O:27]=[C:28]1[NH:32][CH2:31][C:30](=[O:33])[N:29]1[CH2:34][C:35]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[CH:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:15][CH:14]=3)[C:9]2=[O:26])=[CH:6][CH:7]=1)=[O:36]

Participants

3

Reactant 2

HCID 25125522-(2,5-Dioxoimidazolidin-1-yl)acetic acidHCID 102468281-(4-Aminophenyl)-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one

Product 1

HCID 103451942-(2,5-Dioxo-imidazolidin-1-yl)-N-{4-[2-oxo-3-(4-phenoxy-phenyl)-2,3-dihydroimidazol-1-yl]-phenyl}-acetamide

Procedure

1-(4-Aminophenyl)-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one was reacted with 2-(2,5-dioxo-imidazolidin-1-yl acetic acid as described in example 217. The product with the molecular weight of 483.49 (C26H21N5O5); MS (ESI): 484 ([M+H]+) was obtained as hydrotrifluoroacetate in this way.

Workup

  1. customMS (ESI): 484 ([M+H]+) was obtained as hydrotrifluoroacetate in this way

Sources & evidence

ORD record
ord-cc689936f3db4d92b7188de36a2951ed
Source dataset
uspto-grants-2006_11
Patent number
US07141561B2

Linked notes

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