2,4-Dichloro-5-nitrobenzotrifluoride → (2s)-1-(4-{[5-Chloro-2-nitro-4-(trifluoromethyl)phenyl]amino}phenyl)-2-propanol

HRID 724139Notes

Reaction equation

HRID 724139 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C@@H:24]([OH:26])[CH3:25])=[CH:19][CH:18]=1>>[Cl:1][C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:23][C@@H:24]([OH:26])[CH3:25])=[CH:21][CH:22]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 6211792,4-Dichloro-5-nitrobenzotrifluorideHCID 67099494(S)-1-(4-aminophenyl)propan-2-ol

Product 1

HCID 67099535(2s)-1-(4-{[5-Chloro-2-nitro-4-(trifluoromethyl)phenyl]amino}phenyl)-2-propanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 162 from 2,4-dichloro-5-nitrobenzotrifluoride and (2S)-1-(4-aminophenyl)-2-propanol (step 2 of Example 248).

Sources & evidence

ORD record
ord-32a4d9fb7108483b9630fe72baf29a44
Source dataset
uspto-grants-2006_11
Patent number
US07141580B2

Reaction notes

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