3-Fluorophenol → Tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate

HRID 72414Notes

Reaction equation

HRID 72414 reaction equation
[C:1]([N:8]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[F:14][C:15]1[CH:16]=[C:17](O)[CH:18]=[CH:19][CH:20]=1>>[F:14][C:15]1[CH:20]=[C:19]([CH:18]=[CH:17][CH:16]=1)[O:13][CH:10]1[CH2:11][CH2:12][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9]1

Participants

3

Reactant 2

HCID 97433-FluorophenolHCID 44169391-Boc-3-pyrrolidinol

Product 1

HCID 67958315Tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylateYield 83.9%

Procedure

The title compound (D37) (1.26 g) was prepared according to the experimental procedure described in Description 34 starting from 1-Boc-3-pyrrolidinol (1 g, 5.34 mmol) and 3-Fluorophenol (0.478 ml, 5.34 mmol).

Sources & evidence

ORD record
ord-b9116eacabd749299f05077d94025138
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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