Methyl 2,5-Dichloronicotinate → HCID 67958051, compound

HRID 72440

Reaction equation

HRID 72440 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[F:13][C:14]([F:27])([F:26])[C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][CH:25]=1)[O:18][CH:19]1[CH2:22][NH:21][CH2:20]1>>[Cl:12][C:9]1[CH:10]=[N:11][C:2]([N:21]2[CH2:22][CH:19]([O:18][C:17]3[CH:23]=[CH:24][CH:25]=[C:15]([C:14]([F:13])([F:27])[F:26])[CH:16]=3)[CH2:20]2)=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

Participants

3

Reactant 2

HCID 2764318Methyl 2,5-DichloronicotinateHCID 111385383-[3-(Trifluoromethyl)phenoxy]azetidine

Product 1

HCID 67958051HCID 67958051, compoundYield 67.4%

Procedure

The title compound (D79) (110 mg) was prepared according to the experimental procedure described in Description 62 starting from Methyl 2,5-dichloronicotinate (87 mg, 0.422 mmol) and 3-(3-(trifluoromethyl)phenoxy)azetidine (D53) (110 mg, 0.506 mmol)

Sources & evidence

ORD record
ord-94e8a92664c14554bdc5553bd79010b1
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Linked notes

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