5-Nitroindole-2-carboxylic acid → HCID 21880795, compound

Reaction equation

[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([C:12]([NH:14][C:15]3[CH:16]=[C:17]4[C:21](=[CH:22][CH:23]=3)[NH:20][C:19]([C:24]([OH:26])=[O:25])=[CH:18]4)=[O:13])=[CH:9][C:8]=2[CH:27]=1)([O-])=O.[N+](C1C=C2C(=CC=1)NC(C(O)=O)=C2)([O-])=O>>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([C:12]([NH:14][C:15]3[CH:16]=[C:17]4[C:21](=[CH:22][CH:23]=3)[NH:20][C:19]([C:24]([OH:26])=[O:25])=[CH:18]4)=[O:13])=[CH:9][C:8]=2[CH:27]=1

Participants

Reactant 2

HCID 3512915-Nitroindole-2-carboxylic acid

HCID 10893859HCID 10893859, compound

Product 1

HCID 21880795HCID 21880795, compound

Procedure

Compound 129 was reduced as described for Compound 126 in Example 115, to give 130 which was used immediately as described in Example 118.

Sources & evidence

ORD record: ord-0ae6a16e3a55455397d7ce95a1c33f1b
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07141680B2

Reaction notes

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