2-Chloro-5-(trifluoromethyl)nicotinic acid → 2-(3-(4-Fluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid
Reaction equation
[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH:7]2[CH2:10][NH:9][CH2:8]2)=[CH:4][CH:3]=1.Cl[C:14]1[N:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:15]=1[C:16]([OH:18])=[O:17]>>[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH:7]2[CH2:8][N:9]([C:14]3[N:22]=[CH:21][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:19][C:15]=3[C:16]([OH:18])=[O:17])[CH2:10]2)=[CH:4][CH:3]=1Participants
3
Procedure
The title compound (D122) (180 mg) was prepared according to the experimental procedure described in Description 121 starting from 3-(4-fluorophenoxy)azetidine) (D49) (177.89 mg, 1.064 mmol) and 2-chloro-5-(trifluoromethyl)nicotinic acid (200 mg, 0.886 mmol)
Sources & evidence
- ORD record
- ord-a1960416f904479985ec4d3e722ad8c2
- Source dataset
- uspto-grants-2014_09