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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 72475Generated: October 27, 2026

3-(Trifluoromethoxy)phenol → 2-(3-(3-(Trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid

https://huagongshe.com/reaction/72475

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethoxy)phenolHCID 2733261—
ReactantMethyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinateHCID 86697871—
Product2-(3-(3-(Trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acidHCID 86697876101%

Reaction Steps

The title compound (D126) (110 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 3-(trifluoromethoxy)phenol (0.043 ml, 0.338 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08828987B2
Source datasetuspto-grants-2014_09
ORD IDord-fb062e8aa52945fa8a34ee36a5756f24
Source noteuspto-grants-2014_09