3-Fluorophenol → HCID 67958637, compound

HRID 72481

Reaction equation

HRID 72481 reaction equation
[F:1][C:2]1[CH:3]=[N:4][C:5]([N:12]2[CH2:15][CH:14]([O:16]S(C)(=O)=O)[CH2:13]2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[F:21][C:22]1[CH:23]=[C:24](O)[CH:25]=[CH:26][CH:27]=1>>[F:1][C:2]1[CH:3]=[N:4][C:5]([N:12]2[CH2:15][CH:14]([O:16][C:26]3[CH:25]=[CH:24][CH:23]=[C:22]([F:21])[CH:27]=3)[CH2:13]2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 97433-FluorophenolHCID 86697878Methyl 5-fluoro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate

Product 1

HCID 67958637HCID 67958637, compoundYield 119.5%

Procedure

The title compound (D132) (108 mg) was prepared according to the experimental procedure described in Description 115 starting from methyl 5-fluoro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D71) (90 mg, 0.295 mmol) and 3-Fluorophenol (0.029 ml, 0.295 mmol).

Sources & evidence

ORD record
ord-c613aafd2f95412e82b2c5be69c870a5
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Linked notes

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