Ethylamine → 2-Ethylamino-3-nitropyridine
Reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]Participants
3
Conditions
- Temperature
- 105 °C
Procedure
A stirred mixture of 2-chloro-3-nitropyridine (50.0 g, 0.32 mol), ethylamine (33.5 g, 0.74 mol), and xylenes (85 mL) was heated at 105° C. in a sealed vessel for three hours. After cooling, the solvent was removed in vacuo, and water was added to the residue. The product was extracted with methylene chloride, dried (sodium sulfate), and concentrated in vacuo to give 56.8 g of the title compound as a brown oil, suitable for use in the next reaction.
Workup
- temperatureAfter cooling
- customthe solvent was removed in vacuo, and water
- additionwas added to the residue
- extractionThe product was extracted with methylene chloride
- dry with materialdried (sodium sulfate)
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-fd116ade73e84ac4897a647ad04306d3
- Source dataset
- uspto-grants-1998_01
- Patent number
- US05705499
Reaction notes
Loading…