Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → HCID 86697880, compound

HRID 72519

Reaction equation

HRID 72519 reaction equation
[F:1][C:2]([F:29])([F:28])[O:3][C:4]1[CH:5]=[C:6]([CH:25]=[CH:26][CH:27]=1)[O:7][CH:8]1[CH2:11][N:10]([C:12]2[N:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:13]=2[C:14](O)=[O:15])[CH2:9]1.Cl.[NH2:31][C:32]1([C:35]2[CH:44]=[CH:43][C:38]([C:39]([O:41][CH3:42])=[O:40])=[CH:37][CH:36]=2)[CH2:34][CH2:33]1>>[F:29][C:2]([F:1])([F:28])[O:3][C:4]1[CH:5]=[C:6]([CH:25]=[CH:26][CH:27]=1)[O:7][CH:8]1[CH2:11][N:10]([C:12]2[N:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][C:13]=2[C:14]([NH:31][C:32]2([C:35]3[CH:44]=[CH:43][C:38]([C:39]([O:41][CH3:42])=[O:40])=[CH:37][CH:36]=3)[CH2:34][CH2:33]2)=[O:15])[CH2:9]1

Participants

3

Reactant 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 866978762-(3-(3-(Trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid

Product 1

HCID 86697880HCID 86697880, compoundYield 73%

Procedure

The title compound (D177) (113 mg) was prepared according to the experimental procedure described in Description 144 starting from 2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D126) (110 mg, 0.26 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (59.31 mg, 0.26 mmol).

Sources & evidence

ORD record
ord-80562b2dd73a400fba157f05a2862491
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Linked notes

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