HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dibromopyridine → 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dibromopyridine | HCID 12274 | — |
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine | HCID 63962797 | 0% |
Reaction Steps
to 2,6-dibromopyridine (100 mg, 0.42 mmol), 4-Aminotetrahydropyran (42.7 mg, 0.42 mmol) in dioxane (3 mL) while bubbling N2 was added Xantphos (24.43 mg, 0.04 mmol), CS2CO3 (316 mg, 0.97 mmol) and palladium(II) acetate (9.48 mg, 0.04 mmol). This was heated in a microwave at 130 oC for 30 mins. A small peak corresponding to product was obseved. Discontinued
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|---|
| ORD ID | ord-13cef69f8e724020954e5476c0d66794 |
| Source note | 750 AstraZeneca ELN dataset |