1-[4-[1-(1-Imidazolyl)-butyl]-phenyl]-ethanol → 4'-[1-(1-Imidazolyl)-butyl]-acetophenone
Reaction equation
[N:1]1([CH:6]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]([OH:18])[CH3:17])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[N:1]1([CH:6]([C:10]2[CH:11]=[CH:12][C:13]([C:16](=[O:18])[CH3:17])=[CH:14][CH:15]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
200 mg of the alcohol of example 7 is stirred in 10 ml of methylene chloride with 1 g of manganese dioxide overnight. It is suctioned off, concentrated by evaporation and the residue is distilled at 180° C./0.03 hPa. 100 mg of the title compound is obtained as colorless oil.
Workup
- concentrationconcentrated by evaporation
- distillationthe residue is distilled at 180° C./0.03 hPa
Sources & evidence
- ORD record
- ord-68934ef1a08b4ddeaccceb3e340fedc0
- Source dataset
- uspto-grants-1991_09
- Patent number
- US05045558
Reaction notes
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