Water → β-AMinoMethyl-benzeneethanol

HRID 727942

Reaction equation

HRID 727942 reaction equation
[NH2:1][CH2:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:4]C(O)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH2:20].[OH-].[Na+]>C(COC)OC>[NH2:1][CH2:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:4][OH:20]

Participants

6

Reactant 4

HCID 962WaterHCID 14113PhenibutHCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydride

Product 1

HCID 11286566β-AMinoMethyl-benzeneethanol

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

For the preparation of the alcohols VI used in Examples (3a) and (3b). 10 g of 3-amino-2-phenylpropanecarboxylic acid in 150 ml of monoglyme were stirred with 3 g of LiAlH4 for 20 hrs. Then, 12 ml of water and 3 ml of 10% sodium hydroxide solution were slowly added thereto. The mixture was filtered and the filtrate was again evaporated with toluene. There was obtained 8.4 g of β-(aminomethyl)-phenethyl alcohol.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was again evaporated with toluene

Sources & evidence

ORD record
ord-94cfd474d910450e9c00447414ac647c
Source dataset
uspto-grants-1991_09
Patent number
US05045567

Linked notes

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