Oxane-4-carboxylic acid → HCID 178523629, compound

Reaction equation

Cl.[F:2][C:3]1[C:4]([F:27])=[CH:5][C:6]2[O:10][N:9]=[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:7]=2[CH:26]=1.[O:28]1[CH2:33][CH2:32][CH:31]([C:34](O)=[O:35])[CH2:30][CH2:29]1>>[F:2][C:3]1[C:4]([F:27])=[CH:5][C:6]2[O:10][N:9]=[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH:25][C:34]([CH:31]5[CH2:32][CH2:33][O:28][CH2:29][CH2:30]5)=[O:35])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:7]=2[CH:26]=1

Participants

Reactant 2

HCID 219302Oxane-4-carboxylic acid

HCID 178479253HCID 178479253, compound

Product 1

HCID 178523629HCID 178523629, compound

Procedure

The title compound, MS: m/e=476.3 (M+H+), was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(5,6-difluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine hydrochloride (example 62, step 1) and tetrahydro-pyran-4-carboxylic acid.

Sources & evidence

ORD record: ord-286228697ba64d37b91b9e378704502c
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08829029B2

Reaction notes

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