4-(2-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide → 4-(2-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:11]([C:22]([NH2:24])=O)[CH2:10]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:11]([CH2:22][NH2:24])[CH2:10]1Participants
3
Procedure
In a manner similar to Preparation 2, react 4-(2-methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide (4.0 g, 16.6 mmol) with lithium aluminum hydride (1.0 g, 26 mmol) to give the title compound.
Workup
- customIn a manner similar to Preparation 2
Sources & evidence
- ORD record
- ord-09ab32eb2f48491aa1e7cbab602ab0ed