Chlorosulfonic acid → HCID 14998830, compound

HRID 728956

Reaction equation

HRID 728956 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[C:6]1([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[N:12]1([C:6]2[CH:11]=[CH:10][C:9]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:8][CH:7]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 815951-Phenylimidazole

Product 1

HCID 14998830HCID 14998830, compound

Procedure

To chlorosulfonic acid cooled to 0° C. in an ice bath is added portionwise 1-phenyl-1H-imidazole. Monitor the progress of the reaction bythin-layer chromatography. When the reaction is complete, quench the mixture on ice. Saturated aqueous NaHCO3 is added until the solution is no longer acidic. Extract the mixture with CH2Cl2. Dry the organic layer over anhydrous Na2SO4 and remove the solvent in vacuo to obtain the title compound.

Workup

  1. customquench the mixture on ice
  2. additionSaturated aqueous NaHCO3 is added until the solution
  3. extractionExtract the mixture with CH2Cl2
  4. dry with materialDry the organic layer over anhydrous Na2SO4
  5. customremove the solvent in vacuo

Sources & evidence

ORD record
ord-6cc879f52e8e41ef9074507710849770
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Linked notes

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